Application

C18 LPA or 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate may be used: to study its effects on Yes-associated protein (YAP) phosphorylation as a standard for the quantification of lysophosphatidicacid(LPA)compoundsin proton samplesusing reversed-phaseultra-performanceliquid chromatography-tandem mass spectrometer (UPLC-MS/MS) as a substrate to investigate the phosphatase activity of soluble epoxide hydrolase (sEH) towards LPA compounds

Biochem/physiol Actions

Lysophosphatidicacid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca²⁺ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.

General description

Lysophosphatidicacid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attachedviaa phosphate group, an aliphatic chain and a hydroxyl group.The aliphatic chain is linked to eithersn-1 orsn-2 position and the phosphate group is connected to thesn-3 position. The hydroxyl group is linked to the remainingsn-1 orsn-2position.

Packaging

5 mL Amber Glass Screw Cap Vial (857228P-1mg)